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IL8 — LTA

Text-mined interactions from Literome

Sugawara et al., Infect Immun 1999 : These LTAs also inhibited the IL-8 inducing activity of B. subtilis LTA on CD14 ( high ) HGF, as did LA-14-PP and anti-CD14 MAb
Blease et al., J Immunol 1999 (Lung Diseases...) : This study investigated the effects of lipoteichoic acid (LTA) , a cell wall component of Gram positive bacteria, alone and with LPS or TNF-alpha, on CAM expression and IL-8 release in human lung microvascular endothelial cells ( HLMVEC ) ... The concentration dependent effects of Staphylococcus aureus ( S. aureus ) LTA ( 0.3-30 microg/ml ) on ICAM-1 and E-selectin expression and IL-8 release were bell shaped ... Streptococcus pyogenes ( S. pyogenes ) LTA had no effect on CAM expression, but caused a concentration dependent increase in IL-8 release ... S. aureus and S. pyogenes LTA ( 30 microg/ml ) abolished LPS induced CAM expression, and S. aureus LTA reduced LPS induced IL-8 release ... In contrast, the effects of S. aureus LTA with TNF-alpha on CAM expression and IL-8 release were additive
Yang et al., Infect Immun 2001 : Anti-CD14 monoclonal antibody ( MAb ) MY4, anti-TLR4 MAb HTA125, and the synthetic lipid A precursor LA-14-PP almost completely inhibited the IL-8 inducing activities of LTA as well as LPS on OCT treated THP-1 cells, but these treatments increased MDP activity
Morath et al., Infect Immun 2002 : After purification, the commercial LTA from Bacillus subtilis and S. pyogenes but not LTA from S. aureus induced the release of tumor necrosis factor alpha, interleukin 1 beta (IL-1beta), IL-6, and IL-10 in human blood
Chang et al., Exp Cell Res 2002 : Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation
Uehara et al., J Med Microbiol 2002 : Anti-TLR2 and anti-TLR4 monoclonal antibodies ( MAbs ) inhibited the IL-8 production induced by PGN and LTA as well as LPS, respectively, in IFN-gamma primed oral epithelial cells, whereas neither MAb inhibited IL-8 production induced by MDP
Nasu et al., Fertil Steril 2003 : The effects of IL-13 and TNF-beta , on the production of IL-6, IL-11, leukemia inhibitory factor (LIF), IL-8 , growth regulated oncogene alpha ( GROalpha ), monocyte chemoattractant protein-1 ( MCP-1 ), regulated on activation, T-cell expressed and secreted ( RANTES ), and eotaxin were investigated
Pantschenko et al., Oncol Rep 2003 (Breast Neoplasms) : TNF-alpha and TNF-beta induced a 3- to 24-fold increase in IL-8 protein expression of BEC, and a 2- to 8-fold increased IL-8 expression in estrogen independent BCC cell lines and no significant IL-8 expression in estrogen dependent cell lines
Otte et al., Gastroenterology 2003 (Inflammatory Bowel Diseases) : Stimulation with LTA or LPS resulted in activation of the mitogen activated protein kinases pathway, nuclear translocation of p65, and significantly increased IL-8 secretion
Lotz et al., J Leukoc Biol 2004 : Moreover, LTA treatment induced the release of proinflammatory cytokines such as interleukin-8 , tumor necrosis factor alpha, and granulocyte-colony stimulating factor by PMN
von Aulock et al., Immunobiology 2003 : However, LTA induced a strong release of the chemoattractants LTB4, IL-8 , C5a, MCP-1 and the colony stimulating factor G-CSF in whole blood comparable to stimulation with the same concentration of LPS ( S. abortus equi )
Bazzocchi et al., Vet Immunol Immunopathol 2005 : We also show that stimulation of purified PMNs with lipoteichoic acid (LTA) , a ligand of TLR2, leads to the release of proinflammatory chemokine IL-8
Hattar et al., Crit Care Med 2006 (Sepsis...) : Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14 dependent, Toll-like-receptor independent mechanism : Autocrine role of tumor necrosis factor- [ alpha ] in mediating LTA induced interleukin-8 generation ... In contrast, IL1-beta was not involved in LTA induced IL-8 generation
Paik et al., Lab Invest 2006 (Fibrosis...) : TNF-alpha and IL-1beta significantly upregulated the expression of TLR2 mRNA and protein in HSCs. PGN and LTA induced NF-kappaB activation and stimulated production of IL-8 in HSCs. Pretreatment with TNF-alpha or IL-1beta augmented NF-kappaB activation and IL-8 production in response to PGN or LTA
Kanczkowski et al., Horm Metab Res 2007 (Adrenal Cortex Neoplasms) : Pam3CSK4 and LTA-TLRs ligands associated with microdomains induce IL8 production in human adrenocortical cancer cells
Galatowicz et al., Clin Exp Allergy 2007 (Conjunctivitis, Allergic...) : For conjunctival biopsy derived cultures ( n=11 ), FcepsilonR1 stimulation increased histamine, TNF-alpha, TNF-beta , IL-5 and IL-8 levels and the production of IL-5, IL-6 ( P < 0.05 ), histamine and IL-8 ( P < 0.01 ) was inhibited by epinastine
Jana et al., Immunology 2009 : Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
Bayraktar et al., Am J Reprod Immunol 2009 : IL-6 and IL-8 were induced to comparable levels in response to both LTA and LPS whereas monocyte chemotactic protein-1 (MCP-1) production was induced more by LTA, demonstrating a differential placental response to a specific toll-like receptor ( TLR ) ligand
Bougarn et al., Clinical and vaccine immunology : CVI 2010 (Mastitis, Bovine...) : LTA induced IL-8 production did not depend on platelet activating factor receptor ( PAFR ), as the PAFR antagonist WEB2086 was without effect
Som et al., Clinical and vaccine immunology : CVI 2012 (Disease Models, Animal...) : Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-10 in response to S. aureus or LTA , but no other TLR2 ligands
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Standiford et al., Infect Immun 1994 (Endocarditis, Bacterial...) : Our findings indicate that LTA can induce the secretion of the polymorphonuclear leukocyte chemotactic factor IL-8 and that LTA may be an important cellular mediator of inflammatory cell recruitment that characterizes immune responses to gram positive bacterial infections
Sugiyama et al., Infect Immun 1996 : In contrast, LPS induced interleukin 1 activity in human gingival epithelial cells in culture, while LTA had little effect
Grunenberg et al., Infusionsther Transfusionsmed 1995 (Blood Group Incompatibility) : IL-1beta, IL-8 increased steadily in all units and TNF-beta in 3 out of 7 from undetectable levels to concentrations of the lower standard ranges
Worm et al., Immunology 1998 (Hypersensitivity) : Stimulation of human B cells with anti-CD40 + interleukin-4 ( IL-4 ) results not only in proliferation and immunoglobulin E ( IgE ) -production, but also increased production of the cytokine lymphotoxin-alpha (LT-alpha) ( formerly also known as tumour necrosis factor-beta (TNF-beta) )