Gene interactions and pathways from curated databases and text-mining

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IL1R1 — TNF

Text-mined interactions from Literome

Millward-Sadler et al., Arthritis Res Ther 2009 (Intervertebral Disc Degeneration) : Quantitative real-time polymerase chain reaction was used to assess the effect of TNF-alpha or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3, -9 and -13, TNF-alpha, TNF receptor 1 (TNF-R1), TNF receptor 2 (TNF-R2), IL-1alpha, IL-1beta, IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra)
González-Navajas et al., J Exp Med 2010 (Colitis) : We show that IL-1R type I (IL-1RI) is essential for TLR9 dependent activation of tumor necrosis factor receptor associated factor 3 ( TRAF3 ) and for production of the antiinflammatory cytokines IL-10 and type I interferon ( IFN )
Bruserud et al., Eur J Haematol 1996 (Acute-Phase Reaction...) : IL1RA release from AML blasts was also increased by stem cell factor, tumour necrosis factor alpha (TNF alpha) , granulocyte-macrophage colony stimulating factor and macrophage colony stimulating factor, whereas interleukin 3, interleukin 6, leukaemia inhibitory factor and granulocyte colony stimulating factor did not significantly alter IL1RA release
van der Poll et al., J Immunol 1997 (Endotoxemia) : We sought to determine by FACS analysis changes in the expression of TNF receptors (TNFR) and type II IL-1R on circulating monocytes and granulocytes during endotoxemia in vivo, and the role of endogenous TNF in these changes
Boelen et al., J Endocrinol 1997 (Euthyroid Sick Syndromes) : The LPS induced release of cytokines was affected by previous immunoneutralization as compared with control experiments with normal immunoglobulin ( IgG ) : anti-IL-1R did not affect serum TNF alpha but decreased serum IL-6, anti-TNF alpha decreased serum TNF alpha but not IL-6, anti-IL-6 did not affect serum TNF alpha but hugely increased IL-6 and anti-IFN gamma decreased both serum TNF alpha and IL-6