Liu et al., Pharm Res 2009
:
Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes ... The enhancing effects of protamine on the proliferative activity of HGF were investigated in vivo, in primary cultured rat hepatocytes, and in perfused rat liver ... The enhancing effect of protamine on the mitogenic activity of HGF on hepatocytes requires pretreatment with protamine for a short period presumably required for its binding to cell-surface heparin, implying possible regulation of c-met autophosphorylation by HSPG
Liu et al., Am J Physiol 1998
:
The effect of protamine on the proliferative activity of hepatocyte growth factor (HGF) was examined in alpha-naphthyl isothiocyanate intoxicated rats