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CDK2 — IFNG
Text-mined interactions from Literome
Dey et al., Biochim Biophys Acta 2000
:
Cell cycle independent
induction of D1 and D2 cyclin expression, but not
cyclin-Cdk complex formation or Rb phosphorylation, by
IFNgamma in macrophages
Hiroi et al., J Biol Chem 2009
(Carcinoma, Squamous Cell...) :
IFNgamma inhibited cyclin A2 (CcnA2) associated kinase activity, which correlated with the
IFNgamma mediated down-regulation of CcnA2 and
Cdk2 expression at both the transcriptional and post-transcriptional level in HSC-2 cells but not in Ca9-22 cells ... These results indicate that the resistance of OSCC to IFNgamma is not due simply to the deficiency in STAT1 dependent signaling but results from a defect in the signaling component that mediates this
IFNgamma induced down-regulation of CcnA2 and
Cdk2 expression at the transcriptional and post-transcriptional levels
Mandal et al., Oncogene 1998
:
The observed
IFN-gamma mediated
inhibition of
CDK-2 and CDK-4 kinase activity was due to enhanced interactions with p21WAF1 and p27Kip1, respectively