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AKT1 — ATR
Text-mined interactions from Literome
Caporali et al., Mol Pharmacol 2008
(Breast Neoplasms...) :
AKT is activated in an
ataxia-telangiectasia and Rad3-related dependent manner in response to temozolomide and confers protection against drug induced cell growth inhibition ... Inhibition of ATM expression in colon cancer cells by siRNA did not impair TMZ induced activation of AKT, whereas siRNA mediated inhibition of
ATR prevented
AKT activation in response to the drug and increased cell chemosensitivity
Xu et al., Journal of oncology 2012
:
Conversely,
Akt is activated by DNA double-strand breaks ( DSBs ) in a DNA-PK- or
ATM/ATR dependent manner and in some circumstances can contribute to radioresistance by stimulating DNA repair by nonhomologous end joining ( NHEJ )