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CD4 — HMGB1

Text-mined interactions from Literome

Huang et al., Shock 2009 (Burns) : The excessively released HMGB1 might stimulate CD4+CD25+Treg activity via binding RAGE on the surface of Tregs and trigger a shift of T ( H ) 1 to T ( H ) 2 with suppression of T-lymphocyte immune function after burn injury
Zhao et al., Cytokine 2012 (Calcium Signaling) : Up-regulation of Mfn2 attenuated the suppressive effect of HMGB1 on CD4 ( + ) T lymphocytes, which was associated with profound elevation of intracellular calcium concentration ( [ Ca ( 2+ ) ] ( i ) ) and nuclear factor of activated T cells ( NFAT ) activity