Gene interactions and pathways from curated databases and text-mining

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NOS2 — REL

Text-mined interactions from Literome

Weidenbach et al., J Hepatol 2000 (Colitis...) : Although low levels of portal endotoxin were measured during the first 2 days of colitis, no significant NF-kappaB/Rel activity and NOS2 induction were detected in the liver
Kang et al., J Pharmacol Exp Ther 2002 : Collectively, these results suggest that silymarin inhibits nitric oxide production and iNOS gene expression by inhibiting NF-kappaB/Rel activation
Jeon et al., J Ethnopharmacol 2006 : KIOM-79 inhibits LPS induced iNOS gene expression by blocking NF-kappaB/Rel and p38 kinase activation in murine macrophages ... Collectively, this series of experiments indicates that KIOM inhibits iNOS gene expression by blocking NF-kappa/Rel and p38 kinase signaling
Cieslik et al., Mol Pharmacol 2006 : Essential role of C-Rel in nitric-oxide synthase-2 transcriptional activation : time dependent control by salicylate
Li et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010 : This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS induced expression of iNOS gene and activation of NF-?B/Rel in RAW 264.7 cells ... Collectively, the results of the series of experiments indicate that magnolol inhibits iNOS gene expression by blocking NF-?B/Rel and p38 kinase signaling
Hwang et al., Nitric Oxide 2013 : Glucosamine inhibits lipopolysaccharide stimulated inducible nitric oxide synthase induction by inhibiting expression of NF-kappaB/Rel proteins at the mRNA and protein levels ... We show that GlcN selectively inhibits sustained iNOS induction by inhibiting Rel protein expression at both the mRNA and protein levels ; such expression is required for prolonged iNOS induction by LPS
Xie et al., J Biol Chem 1994 : Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase