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WRN — XRCC5

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: WRN — XRCC5 (physical association, affinity chromatography technology) Li et al., J Biol Chem 2004*
• IRef Biogrid Interaction: WRN — XRCC5 (physical association, affinity chromatography technology) Sand-Dejmek et al., Molecular cancer 2011
• IRef Biogrid Interaction: WRN — XRCC5 (physical association, affinity chromatography technology) Partridge et al., Mol Biol Cell 2003*
• IRef Biogrid Interaction: WRN — XRCC5 (physical association, affinity chromatography technology) Karmakar et al., Nucleic Acids Res 2002*
• IRef Biogrid Interaction: WRN — XRCC5 (direct interaction, pull down) Karmakar et al., Nucleic Acids Res 2002*
• IRef Biogrid Interaction: WRN — XRCC5 (physical association, affinity chromatography technology) Li et al., J Biol Chem 2000*
• IRef Biogrid Interaction: WRN — XRCC5 (direct interaction, pull down) Cooper et al., Genes Dev 2000*
• IRef Biogrid Interaction: WRN — XRCC5 (physical association, affinity chromatography technology) Cooper et al., Genes Dev 2000*
• IRef Biogrid Interaction: WRN — XRCC5 (physical association, affinity chromatography technology) Orren et al., Nucleic Acids Res 2001*
• MIPS CORUM Ku70/Ku86/Werner complex: Ku70/Ku86/Werner complex complex (WRN-XRCC5-XRCC6) Cooper et al., Genes Dev 2000*
• MIPS CORUM WRN-Ku70-Ku80-PARP1 complex: WRN-Ku70-Ku80-PARP1 complex complex (PARP1-WRN-XRCC5-XRCC6) Li et al., J Biol Chem 2004*
• IRef Hprd Interaction: WRN — XRCC5 (in vitro) Cooper et al., Genes Dev 2000*, Li et al., J Biol Chem 2000*, Karmakar et al., Nucleic Acids Res 2002*
• IRef Hprd Interaction: WRN — XRCC5 (in vivo) Cooper et al., Genes Dev 2000*, Li et al., J Biol Chem 2000*, Karmakar et al., Nucleic Acids Res 2002*
• IRef Intact Interaction: Complex of PARP1-DDX17-SUPT16H-XRCC5-TOP1-WRN-XRCC6-TMPO (physical association, tandem affinity purification) Sand-Dejmek et al., Molecular cancer 2011
• IRef Intact Interaction: Complex of 248 proteins (association, pull down) von Eyss et al., EMBO J 2012
• IRef Intact Interaction: Complex of 22 proteins (association, anti bait coimmunoprecipitation) Orren et al., Nucleic Acids Res 2001*
• IRef Intact Interaction: Complex of 25 proteins (association, anti bait coimmunoprecipitation) Li et al., J Biol Chem 2004*
• IRef Ophid Interaction: WRN — XRCC5 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: WRN — XRCC5 (aggregation, confirmational text mining) Karmakar et al., Nucleic Acids Res 2002*

Text-mined interactions from Literome

Li et al., J Biol Chem 2004 (Werner Syndrome) : Significantly, ( ADP-ribosyl ) ation of Ku70/80 reduces the ability of this factor to stimulate WRN exonuclease, suggesting that covalent modification of Ku70/80 by PARP-1 may play a role in the regulation of the exonucleolytic activity of WRN
Perry et al., Nature structural & molecular biology 2006 : The DNA end binding Ku70/80 complex specifically stimulates WRN-exo activity, and structure based mutational inactivation of WRN-exo alters DNA end joining in human cells