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CA2 — CLCA1

Text-mined interactions from Literome

Pauli et al., Clin Exp Pharmacol Physiol 2000 : 1. In the present brief review, we describe some of the molecular and functional characteristics of a novel mammalian family of putative Ca2+ activated chloride channels ( CLCA )
Kotlikoff et al., Novartis Found Symp 2002 : These Ca2+ gated SR Ca2+ channels produce unitary Ca2+ sparks, which in turn open Ca2+ activated membrane ion channels such as Ca2+ activated Cl- channels ( ClCa ) and Ca2+ activated K+ channels
Ledoux et al., J Physiol 2003 : The role of the Ca2+ dependent phosphatase calcineurin ( CaN ) in the modulation of Ca2+ dependent Cl- channels ( ClCa ) was studied in freshly isolated rabbit coronary arterial myocytes
Lee et al., J Physiol 2005 (Calcium Signaling...) : The Ca2+ activated Cl- channel ( CLCA ) inhibitor, niflumic acid ( NFA, 100 microM ), significantly reduced BK-induced action potential discharge to 21 +/- 7 % of the control BK response
Linley et al., J Membr Biol 2009 (Calcium Signaling...) : The activation of I ( CLCA ) by depolarization was reduced by lowering extracellular Ca2+ and completely inhibited by buffering cytosolic Ca2+ with EGTA, suggesting a role for Ca2+ influx in the activation of I(CLCA) ... Therefore I ( CLCA ) is dependent on both an increase in intracellular Ca2+ and depolarization to be active