Kutuzov et al., FASEB J 2007
:
Constitutively activated G alpha13Q226L increased ASK1 expression ... Data showed that G alpha13Q226L reduced the rate of ASK1 degradation, decreased ASK1 ubiquitination, and reduced association of ASK1 with an E3 ubiquitin ligase CHIP, previously shown to mediate ASK1 degradation ... Our findings indicate that ASK1 expression levels can be regulated by G alpha13 , at least in part via control of ASK1 ubiquitination and degradation
Berestetskaya et al., J Biol Chem 1998
:
Moreover, the mutationally activated Galpha12 and Galpha13 stimulated the kinase activity of ASK1