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CTNNB1 — JUN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: JUN → CTNNB1 (increases, JUN Activity)
  Evidence: we next investigated target genes of b-catenin, in particular, c-Jun, c-Myc, and cyclin D1, and their possible contribution to the anti-MM effect of enzastaurin. Our results show that b-catenin induces c-Jun, whereas c-Myc was markedly down-regulated #(this is protein - western blots in fig 3A)
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3) → MYC (MYC) (transcription, activates) Gan et al., J Cell Biol 2008
  Evidence: reporter gene, physical interaction
• NCI Pathway Database AP-1 transcription factor network: beta catenin (CTNNB1) → JUN/FOS complex (FOS-JUN) (modification, collaborate) Nateri et al., Nature 2005, Toualbi et al., Oncogene 2007
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: beta catenin (CTNNB1) → JUN/FOS/TCF4/beta catenin complex (FOS-JUN-TCF7L2-CTNNB1) (modification, collaborate)
  Nateri et al., Nature 2005, Toualbi et al., Oncogene 2007
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: TCF4 (TCF7L2) → JUN/FOS/TCF4/beta catenin complex (FOS-JUN-TCF7L2-CTNNB1) (modification, collaborate)
  Nateri et al., Nature 2005, Toualbi et al., Oncogene 2007
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOS complex (FOS-JUN) → JUN/FOS/TCF4/beta catenin complex (FOS-JUN-TCF7L2-CTNNB1) (modification, collaborate)
  Nateri et al., Nature 2005, Toualbi et al., Oncogene 2007
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → JUN (JUN) (modification, collaborate) Gan et al., J Cell Biol 2008
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3) (modification, collaborate)
  Gan et al., J Cell Biol 2008
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: JUN (JUN) → TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3) (modification, collaborate)
  Gan et al., J Cell Biol 2008
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: DVL3 (DVL3) → TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3) (modification, collaborate)
  Gan et al., J Cell Biol 2008
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of JUN-CTNNB1-TCF7L2 Nateri et al., Nature 2005
• MIPS CORUM JUN-TCF4-CTNNB1 complex: JUN-TCF4-CTNNB1 complex complex (CTNNB1-JUN-TCF4) Nateri et al., Nature 2005
• IRef Corum Interaction: Complex of CTNNB1-TCF4-JUN (association, pull down) Nateri et al., Nature 2005
• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
• IRef Innatedb Interaction: CTNNB1 — JUN (unknown, -) Nateri et al., Nature 2005
• IRef Innatedb Interaction: CTNNB1 — JUN (unknown, -) Toualbi et al., Oncogene 2007

Text-mined interactions from Literome

Nateri et al., Nature 2005 (Intestinal Neoplasms) : Chromatin immunoprecipitation assays revealed JNK dependent c-Jun-TCF4 interaction on the c-jun promoter, and c-Jun and TCF4 cooperatively activated the c-jun promoter in reporter assays in a beta-catenin dependent manner
Toualbi et al., Oncogene 2007 : Promoter studies indicate that overexpression of AP-1 activates the transcription of two beta-catenin target genes, cyclin D1 and c-myc, by a mechanism independent of the AP-1 site, and fully dependent on the TCF binding site
Salisbury et al., Mol Endocrinol 2009 : Together, these results indicate that GnRH regulation of Jun transcription requires a functional interaction between TCF/LEF and beta-catenin and that alteration of either impacts expression of JUN downstream targets such as Cga