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CXCL10 — PGF

Text-mined interactions from Literome

Wallace et al., Cancer Res 2009 (Adenocarcinoma...) : This study found that PGF ( 2alpha ) signaling via FP regulates expression of chemokine ( C-X-C motif ) ligand 1 ( CXCL1 ) in endometrial adenocarcinoma cells
Sales et al., Biochim Biophys Acta 2009 (Adenocarcinoma...) : We found that PGF ( 2alpha ) -FP receptor interaction induces CXCL8 expression in endometrial adenocarcinoma cells via the protein kinase C-calcium-calcineurin-NFAT signaling pathway ... Promoter analysis revealed that CXCL8 transcriptional activation by PGF ( 2alpha ) signaling is mediated by cooperative interactions between the AP1 and NFAT binding sites ... Taken together our data have elucidated the molecular and cellular mechanism whereby PGF ( 2alpha ) regulates CXCL8 expression via the FP receptor in endometrial adenocarcinomas and have highlighted RCAN1-4 as a negative regulator of CXCL8 expression which may be exploited therapeutically to inhibit CXCL8 mediated tumour development
Chaturvedi et al., J Clin Invest 2013 (Breast Neoplasms...) : MSC coculture did not enhance the metastasis of HIF-deficient BCCs. BCCs and MSCs expressed placental growth factor (PGF) and its cognate receptor VEGFR1, respectively, in a HIF dependent manner, and CXCL10 expression by MSCs was dependent on PGF expression by BCCs. PGF promoted metastasis of BCCs and also facilitated homing of MSCs to tumors