Shumway et al., Biochem J 2004
(Lymphoma, B-Cell) :
Inducible activation of the transcription factor NF-kappaB ( nuclear factor kappaB ) is classically mediated by proteasomal degradation of its associated inhibitors, IkappaBalpha ( inhibitory kappaBalpha ) and IkappaBbeta Griffin et al., Biochem J 2006
:
This accounts for the differential expression of IkappaB family members in response to NF-kappaB activation and furthers our understanding of the mechanisms involved in transcription factor activity and IkappaBbeta gene regulation