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TP53 — XPC
Text-mined interactions from Literome
Amundson et al., Cancer Biol Ther 2002
:
We now show that
XPC is induced in a variety of human cell lines in response to both ionizing and ultra-violet ( UV ) radiation and alkylating agents, and that this induction
requires wild-type
p53
Adimoolam et al., Proc Natl Acad Sci U S A 2002
:
Furthermore, regulated expression of wild-type
p53 in p53 null Li-Fraumeni syndrome human fibroblasts significantly
augmented the expression of
XPC protein
Ford et al., Mutat Res 2005
:
The mechanisms involved in this process include both transcriptional and post-translational
regulation by
p53 of the DDB2 and
XPC gene products, two critical DNA damage recognition proteins required for GGR
Hardy et al., Anticancer Res 2010
(Bone Neoplasms...) :
The p53 tumor suppressor pathway regulates the G ( 1 ) /S checkpoint by regulating the cyclin dependent kinase inhibitor p21 ( Waf1/Cip1 ), but
p53 also
regulates the nucleotide excision DNA repair protein
XPC