Gene interactions and pathways from curated databases and text-mining

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F2R — MMP13

Text-mined interactions from Literome

Wang et al., Gynecol Oncol 2011 (Neoplasm Invasiveness...) : Furthermore, MMP-1 and PAR1 were both significantly induced by LPA ( 20 µM ), and siRNA silencing of MMP-1 and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 )
Jaffré et al., Circulation 2012 : In the present study, we hypothesized that ß-AR stimulation would result in MMP dependent PAR1 transactivation in cardiac cells ... Finally, we demonstrated that either PAR1 genetic ablation or pharmacological inhibition of MMP-13 prevented isoproterenol dependent cardiac dysfunction in mice