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PLD4 — PTGS2
Text-mined interactions from Literome
Park et al., Mol Pharmacol 2002
:
Regulation of
cyclooxygenase-2 expression by
phospholipase D in human amnion derived WISH cells ... In addition, evidence that
PLD was
involved in the stimulation of
COX-2 expression was provided by the observations that COX-2 expression was stimulated by the dioctanoyl phosphatidic acid ( PA ) and that the prevention of PA dephosphorylation by 1-propranolol potentiated COX-2 expression by IL-1 beta ... The results of this study indicate that in human amnion cells, IL-1 beta might activate
PLD through an upstream protein kinase C to elicit p38 and finally
induce COX-2 expression
Grab et al., Biochim Biophys Acta 2004
:
Differential
role for
phospholipase D1 and phospholipase D2 in 12-O-tetradecanoyl-13-phorbol acetate stimulated MAPK activation,
Cox-2 and IL-8 expression
Kim et al., J Biol Chem 2004
(Astrocytoma) :
Furthermore, evidence that
PLD was
involved in EGCG induced
COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid ( PA ), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG ... Collectively, our results demonstrate for the first time that
PLD isozymes
mediate EGCG induced
COX-2 expression through PKC and p38 in immortalized astroglial line and normal astrocyte cells
Ahn et al., Biochim Biophys Acta 2007
(Astrocytoma) :
In addition, evidence that
PLD activity was
involved in the stimulation of
COX-2 expression was provided by the observations that overexpression of wild type PLD isozymes, but not catalytically inactive PLD isozymes, stimulated CoCl ( 2 ) -induced COX-2 expression and PGE ( 2 ) production