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MAPK9 — NFATC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
JNK2 (MAPK9)
→
NFATc (NFATC1)
(transcription, inhibits)
Conze et al., J Exp Med 2002, Teixeira et al., J Immunol 2005
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
JNK2 (MAPK9)
→
JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3)
(transcription, inhibits)
Conze et al., J Exp Med 2002, Kim et al., EMBO J 2002, Jain et al., J Immunol 1992
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
WikiPathways MAPK Signaling Pathway:
MAPK8/MAPK10/MAPK9
→
NFATC1
(mim-inhibition)
Text-mined interactions from Literome
Wu et al., Mol Cell Biol 2003
:
Fourth, p38
MAPK promoted the interaction of
NFATc with the coactivator CREB binding protein ... All together, the overall
effect of p38
MAPK on
NFATc in T cells is clear activation
Holsinger et al., Curr Biol 1998
:
Activation of Jun N-terminal kinase or stress activated kinase ( JNK or SAPK ) and
mitogen activated protein kinase ( MAPK ) and the
induction of the transcription factor
NF-ATc1 and egr-1 genes was normal