◀ Back to IGF1R
IGF1R — MDM2
Pathways - manually collected, often from reviews:
-
KEGG Endocytosis:
CBL/CBLB/CBLC/ITCH/MDM2/NEDD4/NEDD4L/RNF41/SMURF1/SMURF2/TRAF6/WWP1
→
CSF1R/EGFR/ERBB3/ERBB4/FGFR2/FGFR3/FGFR4/FLT1/IGF1R/KDR/KIT/MET/NTRK1/PDGFRA/RET
(protein-protein, ubiquination)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
IGF1R
—
MDM2
(direct interaction, enzymatic study)
Sehat et al., Cancer Res 2008
-
IRef Biogrid Interaction:
IGF1R
—
MDM2
(physical association, affinity chromatography technology)
Sehat et al., Cancer Res 2008
-
IRef Biogrid Interaction:
IGF1R
—
MDM2
(physical association, affinity chromatography technology)
Girnita et al., Proc Natl Acad Sci U S A 2003*
-
IRef Biogrid Interaction:
IGF1R
—
MDM2
(physical association, affinity chromatography technology)
Broussas et al., Int J Cancer 2009*
-
IRef Hprd Interaction:
IGF1R
—
MDM2
(in vivo)
Girnita et al., Proc Natl Acad Sci U S A 2003*, Sehat et al., Cancer Res 2008
-
IRef Hprd Interaction:
IGF1R
—
MDM2
(in vitro)
Girnita et al., Proc Natl Acad Sci U S A 2003*, Sehat et al., Cancer Res 2008
-
IRef Intact Interaction:
IGF1R
—
MDM2
(physical association, display technology)
Miyamoto-Sato et al., PloS one 2010
Text-mined interactions from Literome
Froment et al., Cell cycle (Georgetown, Tex.) 2008
:
Consistent with the ability of Mdm2 to promote ubiquitylation and proteasome destruction of IGFR-I independently of p53, we show herein that loss of
Mdm2 leads to a significant increase in
IGF1-R-beta protein levels both in cells lacking or expressing p53
Shen et al., FEBS open bio 2012
:
These results mean that sunitinib mediates ubiquitination of
IGF-1R dependent on
MDM2