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IRS2 — SH2B1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
IRS2
→
SH2B1
(direct_complex)
Szanto et al., Proc Natl Acad Sci U S A 2000, Martín-Romero et al., Cell Immunol 2001, Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007, Hill et al., J Clin Invest 2008, Buettner et al., Nat Med 2008, Bjørbaek et al., J Biol Chem 1997
-
Reactome Reaction:
IRS2
→
SH2B1
(reaction)
Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007
Text-mined interactions from Literome
Duan et al., Mol Cell Biol 2004
(Glucose Intolerance...) :
Moreover,
SH2-B directly
enhanced autophosphorylation of insulin receptor and tyrosine phosphorylation of IRS1 and
IRS2 in an SH2 domain dependent manner in cultured cells
Duan et al., J Biol Chem 2004
:
Consequently,
SH2-B dramatically
enhanced leptin stimulated tyrosine phosphorylation of IRS1 and
IRS2 in HEK293 cells stably expressing LRb, thus promoting association of IRS1 and IRS2 with the p85 regulatory subunit of PI 3-kinase and phosphorylation and activation of Akt
Duan et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010
(Obesity) :
SH2B1 dramatically
enhanced the leptin stimulated tyrosine phosphorylation of JAK2 and
IRS2 in HEK293 cells stably expressing LRb ( HEK239 ( LRb ) )