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ERBB2 — TNF

Text-mined interactions from Literome

Yamaoka et al., Proc Natl Acad Sci U S A 2008 : This study was undertaken to determine the effects of TNF on EGFR and ErbB2 activation and intestinal epithelial cell survival ... TNF also activated ErbB2, and loss of ErbB2 expression increased TNF induced apoptosis
Rivas et al., Breast Cancer Res Treat 2010 (Breast Neoplasms...) : We found that TNFalpha induces ErbB-2 phosphorylation in mouse breast cancer C4HD cells and in the human breast cancer cell lines SK-BR-3 and BT-474 ... ErbB-2 phosphorylation at Tyr877 residue was mediated by TNFalpha induced c-Src activation ... Moreover, TNFalpha promoted ErbB-2/ErbB-3 heterocomplex formation, Akt activation and NF-kappaB transcriptional activation ... Interestingly, our work disclosed that TNFalpha is able to transactivate ErbB-2 and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals
Kalthoff et al., Proc Natl Acad Sci U S A 1993 (Pancreatic Neoplasms) : The inverse regulatory effects of TNF on ERBB2 and EGFR mRNA levels were evoked by different signaling pathways of p55 TNF receptors ... In our study we show that the TNF mediated down-regulation of ERBB2 in pancreatic tumor cells is accompanied by an increase in growth inhibition at low doses of TNF