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CAV1 — INSR
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CAV1
→
INSR
(directlyIncreases, CAV1 Activity)
Evidence: Insulin stimulates the tyrosine phosphorylation of caveolin... Investigation of this pathway revealed the phosphorylation of another insulin receptor substrate, the proto-oncogene c-Cbl... The phosphorylation of Cbl requires the presence of another protein that recruits Cbl to the insulin receptor, which is likely to be the adaptor protein APS (adaptor protein containing PH and SH2 domains).
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cohen et al., Am J Physiol Cell Physiol 2003
(Hyperinsulinism...) :
However, it remains unknown whether
caveolin-1 is normally
required for proper
insulin receptor signaling in vivo
Wharton et al., J Biol Chem 2005
:
However, there are conflicting data concerning the
effects of
caveolin on
insulin receptor expression and function ... We conclude that
insulin receptor expression and ligand dependent signaling is
independent of
caveolin-1 expression
Oh et al., J Cell Biochem 2006
:
However in contrast to adipocytes, phosphorylation of
insulin receptor beta (IRbeta) and Akt/Erk was not
affected by the respective downregulation of
caveolin-1 or caveolin-3 in the muscle cells
Gupta et al., Hypertension 2012
(Disease Models, Animal...) :
When
caveolin or Na/K-ATPase-a1 expression was knocked down with small interfering RNA, insulin but not ouabain
induced carcinoembryonic antigen cell adhesion molecule 1,
insulin receptor-ß , and epidermal growth factor receptor endocytosis