◀ Back to IL10
CD79A — IL10
Text-mined interactions from Literome
Wu et al., Ann Surg 1999
:
To examine the levels of a Th1 IgA inhibiting cytokine ( interferon gamma ) and the Th2
IgA stimulating cytokines ( interleukin [IL]-4, IL-5, IL-6, and
IL-10 ) within the intestine of animals manipulated with enteral or parenteral nutrition, and to correlate these cytokine alterations with intestinal IgA levels
Sánchez-Segura et al., Laryngoscope 2000
(Nasal Polyps) :
The
IgA production is partly
dependent on
IL-10 and TNF-alpha
Perdigón et al., Eur J Clin Nutr 2002
(Colonic Neoplasms...) :
We demonstrated that yoghurt may exert antitumour activity by a decrease in the inflammatory immune response
mediated by
IgA ( + ) increase, apoptosis induction and
IL-10 release
Nies et al., J Investig Allergol Clin Immunol 2002
(Respiratory Hypersensitivity) :
IL-4 supplemented B-cell cultures of allergic children show reduced
IgA and IgG production in
response to additional stimulation with
IL-10 ... The capacity of B cells in allergic children to produce less
IgA and IgG in
response to additional stimulation with
IL-10 of cultures supplemented with IL-4 could play an important role in mediating a mucosal immune system vulnerable to allergens
Béniguel et al., Parasite Immunol 2003
(Schistosomiasis haematobia) :
Exogenous IL-2 and
IL-10 or IL-10 and TGF-beta
led to the production of specific IgG3 or IgG1 and/or
IgA , respectively
Rousset et al., Proc Natl Acad Sci U S A 1992
:
Moreover,
IL-10 induces activated B cells to secrete large amounts of IgG,
IgA , and IgM, and the combination of IL-10 and IL-4 results in the secretion of the four immunoglobulin isotypes
Hirano et al., Immunol Lett 2003
:
CD27 synergizes with CD40 to induce IgM, IgG, and
IgA antibody responses of peripheral blood B cells in the
presence of IL-2 and
IL-10
Asano et al., Clin Exp Immunol 2004
(IgA Deficiency) :
In some patients,
IgA secretion was induced by
stimulation with anti-CD40, IL-4 and
IL-10
Kono et al., Am J Physiol Gastrointest Liver Physiol 2004
:
In addition, the mRNA expression of the Th2
IgA stimulating cytokine
IL-10 in the ileum and Peyer 's patches was significantly greater in the MCTs than the corn oil group
Sunaga et al., Acta Otolaryngol Suppl 2004
(Glomerulonephritis, IGA...) :
In conclusion, IFN-gamma, TGF-beta, and
IL-10 influence each other in the pathogenesis of IgAN, and infection by not only HP but other bacteria or viruses which possess specific DNA sequences such as CpG motifs
induce the production of HP-specific
IgA by TMC
Giri et al., FEMS Immunol Med Microbiol 2005
(Disease Models, Animal...) :
Vaccination via intranasal and subcutaneous routes triggered immune activation in the spleen and cervical lymph node, while the former route of vaccination lead to higher antigen-specific lymphocyte proliferation, interferon-gamma,
interleukin-12 and interleukin-4 responses in cervical lymph node and
induction of antigen-specific
IgA responses at mucosal level of the respiratory tract
Kaneko et al., Immunology 2005
:
These results indicate that high
IgA levels in the intestine of TLR4 mutated mice are
due to up-regulation of TGF-beta and
IL-10 and the lack of regulation by SOCS-1
Kaur et al., Blood 2007
:
Finally, neonatal B cells, particularly preterm B cells, exhibited markedly decreased production of IgG and
IgA in
response to CD40L and
IL-10
Hussain et al., J Immunol 2007
(Diabetes Mellitus, Type 1) :
Consistent with this result, severe insulitis was observed in the islets of NOD recipients of transfused
NOD.IL-10 ( -/- )
BCR stimulated B cells but not in the islets of NOD recipients of transfused BCR stimulated NOD B cells
Sjöblom-Hallén et al., Mucosal Immunol 2010
:
Moreover, IgG1 and
IgA production
induced by LPS and
IL-10 were enhanced by the addition of CT to cultures of PP or splenic B cells
Lecocq et al., J Immunol 2013
:
We showed that
IgA induces
IL-10 in monocytes and dendritic cells
Maiolini et al., BMC veterinary research 2013
(Arteritis...) :
To investigate if transforming growth factor beta 1 ( TGF-ß1 ),
interleukin-6 (IL-6) and vascular endothelial growth factor ( VEGF ) are
involved in the production of excessive
immunoglobulin A (IgA) , the induction of acute phase proteins and in the development of a systemic necrotizing vasculitis, characteristic of SRMA, these three signalling proteins were evaluated
Kunisawa et al., Nature communications 2013
:
CD11b ( + )
IgA ( + ) plasma cells require the lymphoid structure of Peyer 's patches, produce more IgA than CD11b ( - ) IgA ( + ) plasma cells, proliferate vigorously, and
require microbial stimulation and
IL-10 for their development and maintenance
Uhde et al., Int Immunol 2013
:
Neither wild type nor CD83 transgenic (CD83tg) B cells produced any
IL-10 in
response to
BCR stimulation
Banchereau et al., Annu Rev Immunol 1994
:
IL-10 induces naive B cells to produce IgG3, IgG1, and
IgA1 , and further addition of TGF beta permits the secretion of IgA2
Brière et al., J Clin Invest 1994
(IgA Deficiency) :
Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete
IgA
Saiki et al., J Clin Invest 1995
(Immunologic Deficiency Syndromes) :
In every X-HIM patient tested, however, anti-CD40 plus
IL-10 did not
induce class switching from IgM to IgG or
IgA , even in the presence of Staphylococcus aureus Cowan I strain ( SAC )
Burdin et al., J Immunol 1995
:
Blocking
IL-10 inhibited the
IgA secretion ( 25 +/- 2.7 % ) obtained after CD40 activation and the production of IgG, IgA, and IgM ( 24.1 +/- 5.6, 25 +/- 8, and 42 +/- 6.5 %, respectively ) by B lymphocytes undergoing dual ligation of CD40 Ag and AgR
Brière et al., Nouvelle revue française d'hématologie 1993
:
IL-10 induces naive B cells to secrete low but reproducible amounts of IgG and
IgA
Armitage et al., J Immunol 1993
:
IL-2 and
IL-10 specifically
enhance IgM, IgG1, and
IgA production although IL-4, despite costimulating B cell proliferation, does not augment secretion of these isotypes but provided an essential cosignal with CD40L for the production of IgG4 and IgE
Marcelletti et al., Cell Immunol 1996
:
Under these conditions, exogenous
IL-10 minimally
potentiated synthesis of antigen-specific IgM, IgG1, IgG2a, IgG2b, IgG3, and
IgA , but inhibited antigen-specific IgE secretion
Estes et al., Vet Immunol Immunopathol 1996
:
We find that TGF-beta will not solely upregulate IgA production from noncommitted precursors ( sIgM+ ) in coculture with mitogen or with formalin fixed Staphylococcus cowan Strain I ( SAC ), but does have positive effects on
IgA production in the
presence of both IL-2 and
IL-10
Fayette et al., J Exp Med 1997
:
In the
presence of
IL-10 , secretion of
IgA2 by CD40 activated naive B cells could be detected only in response to D-Lc and was further enhanced by TGF-beta
de Fijter et al., Nephrol Dial Transplant 1998
(Glomerulonephritis, IGA) :
Furthermore
IL-10 led to significantly ( P < 0.05 ) lower
IgA1 and IgA2 synthesis in patients than in controls
Nagumo et al., Immunology 1998
:
In the
presence of
IL-10 stimulation, the production of IgG, IgM and
IgA was increased synergistically by the addition of CD27 ligand ( CD70 ) -transfectants in a dose dependent manner, which was completely blocked by anti-CD70 monoclonal antibody