Gene interactions and pathways from curated databases and text-mining

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PPARGC1A — SLC2A4

Text-mined interactions from Literome

Miura et al., J Biol Chem 2003 : To examine whether increased PGC-1alpha expression was also responsible for an increase of GLUT4 expression, transgenic mice that overexpress PGC-1alpha in skeletal muscles driven by a human alpha-skeletal actin promoter were made
Oliveira et al., Am J Physiol Endocrinol Metab 2004 : Inhibition of PGC-1alpha expression in cold exposed rats by antisense oligonucleotide treatment diminished glucose clearance rates during a hyperinsulinemic clamp and reduced expression and membrane localization of GLUT4
Raciti et al., Diabetologia 2010 (Insulin Resistance) : Finally, we showed that overproduction of ATF6 is sufficient to inhibit the expression of genes GLUT4 , MEF2A and PGC1alpha and that ATF6 silencing with a specific small interfering RNA is sufficient to completely prevent glucosamine induced inhibition of GLUT4, MEF2A and PGC1alpha in skeletal muscle cells