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MAPK8 — SREBF1
Text-mined interactions from Literome
Nadeau et al., J Biol Chem 2004
(Insulin Resistance...) :
We determined the roles of the phosphatidylinositol (PI) 3-kinase and
mitogen activated protein ( MAP ) kinase dependent pathways in the effect of mediating insulin on
SREBP-1 in L-6 skeletal muscle cells and 3T3 L1 adipocytes, using wortmannin or LY294002 to inhibit the PI 3-kinase pathway, and PD98059 to inhibit the MAP kinase dependent pathway
Gnoni et al., J Cell Physiol 2012
(Carcinoma, Hepatocellular...) :
Modulation of
SREBP-1 protein level by T ( 3 ) was
dependent on
MAPK/ERK , PI3K/Akt/mTOR-C1 pathway activation since the MEK inhibitor PD98059 or the PI3K inhibitor LY294002 abolished the stimulatory effect of T ( 3 )
Yan et al., Mol Med 2012
:
p38
MAPK was
involved in leptin regulation of
SREBP-1c expression in cultured HSCs. Leptin induced activation of p38 MAPK led to the decreases in liver X receptor ( LXR ) -a protein level, activity and its binding to the SREBP-1c promoter, which caused the downregulation of SREBP-1c expression