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PRDX2 — PTGS2

Text-mined interactions from Literome

Wu et al., Reprod Sci 2007 (Endometriosis) : These results, along with recent findings that TSA suppresses proliferation, interleukin-1 beta induced cyclo-oxygenase 2 expression, and constitutive or TNFalpha stimulated nuclear factor kappa B activation in endometrial and endometriotic cells, makes histone deacetylase inhibitors a promising class of compounds for novel and more effective medical treatment of endometriosis, especially given the mounting evidence that endometrios be an epigenetic disease
Chabane et al., Osteoarthritis Cartilage 2008 : In the present study, we determined the effect of trichostatin A (TSA) and butyric acid ( BA ), two histone deacetylase (HDAC) inhibitors, on NO and PGE ( 2 ) synthesis, inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 expression, and nuclear factor (NF)-kappaB DNA binding activity, in interleukin-1beta (IL-1) stimulated human OA chondrocytes, and on IL-1 induced proteoglycan degradation in cartilage explants