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BNIP3 — E2F1

Text-mined interactions from Literome

Yurkova et al., Circ Res 2008 (Anoxia) : The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes
Shaw et al., Proc Natl Acad Sci U S A 2008 : Conversely, in the absence of NF-kappaB, or during hypoxia when NF-kappaB abundance is reduced, basal Bnip3 gene transcription is activated by the unrestricted binding of E2F-1 to the Bnip3 promoter ... Hence, by way of example, we show that the transcriptional inhibition of E2F-1 dependent Bnip3 expression by NF-kappaB highlights a survival pathway that overrides the E2F-1 tumor suppressor program