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TIMP2 — TNF
Text-mined interactions from Literome
Watari et al., Am J Pathol 1999
:
TNF-alpha increased secretion of procathepsin S, but did not
affect TIMP-1 and reduced
TIMP-2 production
Lévêque et al., Microbes Infect 2004
:
Differential
regulation of gelatinase A and B and
TIMP-1 and -2 by
TNFalpha and HIV virions in astrocytes
Chen et al., Di Yi Jun Yi Da Xue Xue Bao 2004
:
The
effect of exogenous
TNF-alpha and anti-TNF-alpha on the expression of matrix metalloproteinase-2 (MMP-2) and
tissue inhibitor of metalloproteinases-2 ( TIMP-2 ) in human trophoblastic cells was investigated with reverse transcription ( RT ) -PCR ( RT-PCR )
Roy et al., J Biochem 2013
:
Inhibition of PKC-a activity also prevented
TNF-a induced MT1-MMP expression and proMMP-2 activation as well as down regulation of
TIMP-2 expression
Hanemaaijer et al., Biochem J 1993
:
On the other hand, MMP-2 and
TIMP-2 were not affected or were
affected in a variable way by
TNF alpha and/or phorbol ester, suggesting a dissimilar regulation of these proteins
Alexander et al., Curr Eye Res 1998
:
A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ;
TIMP-2 levels are
reduced by
TNF but not affected by the other treatments
Lombard et al., Cancer Res 1998
(Adenocarcinoma...) :
The synthetic MMPIs and
TIMP-2 , but not TIMP-1, also
caused a dose dependent increase in the number of
TNFalpha receptors retained on the surface of Colo 205 cells, as determined by flow cytometry