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ACP2 — TNFSF11
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Mancini et al., Biochem Biophys Res Commun 2000
(Leukemia, Monocytic, Acute) :
We show that
OPGL alone and in combination with macrophage colony stimulating factor ( CSF-1 ) dramatically reduced replication and
increased tartrate-resistant
acid phosphatase activity
Liu et al., J Biol Chem 2003
:
Involvement of upstream stimulatory factors 1 and 2 in
RANKL induced transcription of tartrate-resistant
acid phosphatase gene during osteoclast differentiation
Zhang et al., J Immunol 2003
:
Over-expression of SHP-1 ( C453S ) significantly enhanced the number of tartrate-resistant
acid phosphatase positive multinuclear osteoclast-like cells in
response to
RANKL in a dose dependent manner
Shi et al., Gene 2004
:
YY1 is involved in
RANKL induced transcription of the tartrate-resistant
acid phosphatase gene in osteoclast differentiation
Sørensen et al., J Bone Miner Metab 2007
:
No expression of osteoclast markers was observed in the absence of RANKL, whereas
RANKL dose-dependently
induced the expression of cathepsin K, tartrate-resistant
acid phosphatase ( TRACP ), and matrix metallo proteinase (MMP)-9
Kim et al., Phytother Res 2009
(Bone Resorption) :
( - ) -Saucerneol significantly inhibited the
RANKL induced activity of tartrate-resistance
acid phosphatase ( TRAP, an early marker of osteoclast formation ) and formation of osteoclasts in a dose dependent manner
Kim et al., J Cell Physiol 2009
(Bone Resorption) :
Therefore, we evaluated the effects of 222 natural compounds on the
RANKL induced tartrate-resistance
acid phosphatase ( TRAP ; a marker for osteoclast differentiation ) activity and multinucleated osteoclast formation in RAW264.7 murine macrophage cells
Mazière et al., J Cell Physiol 2009
(Bone Resorption) :
OxLDL, within the range of 10-50 microg protein/ml, prevented
RANKL induced generation of multinucleated osteoclast-like cells and RANKL induced tartrate resistant
acid phosphatase ( TRAP ) activity
Hasegawa et al., Biol Pharm Bull 2010
(Bone Resorption) :
Honokiol markedly inhibited
RANKL induced tartrate-resistant
acid phosphatase ( TRAP ) activity and the formation of TRAP positive multinucleated cells in both bone marrow derived monocytes and RAW264 cells
Okayasu et al., J Biol Chem 2012
(Bone Resorption...) :
Despite these findings, RANK signaling, including the activation of Erk and Akt, was normal in LDLR ( -/- ) preosteoclasts, and
RANKL induced expression of NFATc1 ( a master regulator of osteoclastogenesis ), cathepsin K, and tartrate-resistant
acid phosphatase was equivalent in LDLR-null and wild-type cells
Shim et al., Pharmacognosy magazine 2012
:
ST-WE significantly inhibited
RANKL induced tartrate-resistant
acid phosphatase ( TRAP ) activity and formation of multinucleated osteoclasts in RAW264.7 cells