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IRF6 — LCN2

Text-mined interactions from Literome

Cowland et al., J Immunol 2003 : IL-1beta induces a > 10-fold up-regulation of NGAL expression in the type II pneumocyte derived cell line A549 cells, whereas TNF-alpha, IL-6, and LPS had no effect ... Selectivity for the IL-1 pathway was substantiated by demonstrating that NGAL promoter activity could be induced by LPS stimulation of A549 cells transiently expressing Toll-like receptor 4, which use the same intracellular signaling pathway as the IL-1R
Tadesse et al., Reprod Sci 2011 (Chorioamnionitis...) : IL-1ß, TNF-a, and LPS stimulated NGAL in cytotrophoblast cells ( not syncytiotrophoblast and decidua ) in vitro
Glaros et al., PloS one 2012 : Using primary kidney fibroblasts, we observed that LPS induced LCN2 expression requires a coupled circuit involving an early transient phase of AP-1 path and a late persistent phase of C/EBPd path, both of which are dependent upon the interleukin 1 receptor associated kinase 1 ( IRAK-1 ) ... Taken together, this study has identified an integrated intracellular network involved in the persistent induction of LCN2 by LPS
Srinivasan et al., J Immunol 2012 (Sepsis) : In this study, we report that LPS induced systemic Lcn2 by 150-fold in wild-type mice at 24 h. Relative to wild-type littermates, Lcn2KO mice were markedly more sensitive to endotoxemia, exhibiting elevated indices of organ damage ( transaminasemia, lactate dehydrogenase ) and increased mortality
Hamzic et al., J Neuroendocrinol 2013 (Fever) : Immunohistochemical analysis also revealed that LPS induced lipocalin-2 is expressed by brain endothelial cells and is partly co-localised with cyclooxygenase-2 (Cox-2), the rate limiting enzyme for the production of inflammatory induced prostaglandin E ( 2 ) ( PGE ( 2 ) ), which is the key mediator of fever
Lee et al., Nephron. Experimental nephrology 2012 (Acute Kidney Injury) : LPS also potently induces Lcn2/Ngal expression in podocytes in culture and in glomeruli in vivo
Gómez et al., J Orthop Res 2013 : In addition, inhibition of LPS induced nitric oxide production by aminoguanidine, a selective NOS2 inhibitor, significantly reduced LPS mediated LCN2 expression