Kurosu et al., J Biol Chem 2007
:
Accordingly, FGF19 , but not FGF21, activates FGF signaling in hepatocytes that primarily express FGFR4 and reduces transcription of CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Nakayama et al., J Biol Chem 2011
:
The extracellular effect of fibroblast growth factor-12 (FGF12) remains unknown because FGF12 can not activate any fibroblast growth factor receptors ( FGFRs ), and FGF12 is not currently thought to be released from cells