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MYLIP — ROBO1
Text-mined interactions from Literome
Tie et al., PLoS Genet 2010
(Lymphatic Metastasis...) :
However,
Robo1 , one of several Slit receptors, is negatively
regulated by
miR-218 , thus establishing a negative feedback loop
Small et al., Circ Res 2010
:
Here, we provide evidence that
microRNA (miR)-218 , which is encoded by an intron of the Slit genes,
inhibits the expression of
Robo1 and Robo2 and multiple components of the heparan sulfate biosynthetic pathway ... Using in vitro and in vivo approaches, we demonstrate that
miR-218 directly
represses the expression of
Robo1 , Robo2, and glucuronyl C5-epimerase (GLCE), and that an intact miR-218-Slit-Robo regulatory network is essential for normal vascularization of the retina
Gao et al., Gene 2013
(Genetic Predisposition to Disease...) :
In vitro binding assays further revealed that the rs11134527 variant affects
miR-218 mediated regulation of
Robo1