◀ Back to RHOA

DVL2 — RHOA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of DVL2-RHOA → WNT1 (increases) Habas et al., Cell 2001
  Evidence: Since Daam1 binds to Dvl and RhoA, we tested whether Daam1 forms a ternary complex with Dvl and RhoA. We immunoprecipitated the endogenous RhoA from 293T cells treated with or without Wnt-1 CM. Strikingly, we found that the endogenous Dvl protein is associated with RhoA only upon Wnt stimulation (Figure 2G).
• OpenBEL Selventa BEL large corpus: Complex of DVL2-DVL3-PRKCA-RHOA → WNT3A (increases)
  Evidence: PKCa, PCKb, and PKCmu were associated with both Dvl-2 (Figure 8A) and Dvl-3 (Figure 8B), suggesting that several PKCs are likely included in the Dvl/RhoA complex.
• OpenBEL Selventa BEL large corpus: Complex of DVL2-DVL3-PRKCB-RHOA → WNT3A (increases)
  Evidence: PKCa, PCKb, and PKCmu were associated with both Dvl-2 (Figure 8A) and Dvl-3 (Figure 8B), suggesting that several PKCs are likely included in the Dvl/RhoA complex.
• OpenBEL Selventa BEL large corpus: RHOA → DVL2 (increases, DVL2 Activity) Habas et al., Cell 2001
  Evidence: Since Daam1 binds to Dvl and RhoA, we tested whether Daam1 forms a ternary complex with Dvl and RhoA. We immunoprecipitated the endogenous RhoA from 293T cells treated with or without Wnt-1 CM. Strikingly, we found that the endogenous Dvl protein is associated with RhoA only upon Wnt stimulation (Figure 2G).
• NCI Pathway Database Noncanonical Wnt signaling pathway: DVL/DAAM1 complex (DVL3_DVL1_DVL2-DAAM1) → RHOA/GDP complex (RHOA) (modification, activates) Habas et al., Cell 2001, Endo et al., J Biol Chem 2005, Liu et al., Proc Natl Acad Sci U S A 2008, Yamamoto et al., Dev Cell 2008
  Evidence: mutant phenotype
• Reactome Reaction: DVL2 → RHOA (indirect_complex) Habas et al., Cell 2001, Sagot et al., Nat Cell Biol 2002*, Watanabe et al., Exp Cell Res 2004*, Liu et al., Proc Natl Acad Sci U S A 2008, Tanegashima et al., EMBO J 2008, Lai et al., Cell Res 2009*, Amano et al., Cytoskeleton (Hoboken, N.J.) 2010*
• Reactome Reaction: DVL2 → RHOA (reaction) Habas et al., Cell 2001, Sagot et al., Nat Cell Biol 2002*, Watanabe et al., Exp Cell Res 2004*, Liu et al., Proc Natl Acad Sci U S A 2008, Tanegashima et al., EMBO J 2008, Lai et al., Cell Res 2009*, Amano et al., Cytoskeleton (Hoboken, N.J.) 2010*
• WikiPathways Wnt Signaling Pathway: DVL1/DVL2/DVL3 → Complex of RHOA-RAC1 (activation)
• WikiPathways Wnt Signaling Pathway and Pluripotency: DVL3/DVL2/DVL1 → Complex of RACGAP1-RHOA (mim-stimulation)
• WikiPathways DNA Damage Response (only ATM dependent): DVL2/DVL3/DVL1 → Complex of RHOA-RAC1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: DVL2 — RHOA (in vivo) Habas et al., Genes Dev 2003*
• STRING interaction: DVL2 — RHOA (interaction, mapped from kegg_pathways)
• STRING interaction: RHOA — DVL2 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Endo et al., J Biol Chem 2005 : Wnt-3a dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2
Tsuji et al., Mol Biol Cell 2010 (Neuroblastoma) : However, it has remained unknown which member ( s ) of a Rho-GEF family are involved in Wnt/Dvl induced RhoA activation in mammalian cells ... Our results suggest that p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl induced RhoA activation and neurite retraction in N1E-115 cells
Zhu et al., PloS one 2012 (Breast Neoplasms) : Dvl2 dependent activation of Daam1 and RhoA regulates Wnt5a induced breast cancer cell migration