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ESR1 — NOS2
Text-mined interactions from Literome
Simoncini et al., Arterioscler Thromb Vasc Biol 2003
:
By interacting with phosphatidylinositol 3-kinase (PI3K),
estrogen receptor (ER) alpha
leads to activation of protein kinase Akt and to subsequent increase in endothelial
nitric oxide synthase activity
Kumar et al., Mol Endocrinol 2007
:
In endothelial cells, the disruption of
ER alpha-G alpha i interaction
prevents estradiol induced
nitric oxide synthase activation and the resulting attenuation of monocyte adhesion that contributes to estrogen related cardiovascular protection
Tsutsumi et al., J Endocrinol 2008
:
Here, we report studies to examine the differential
regulation of
NOS2A gene expression by
ESR1 and 2 ... In heterologous expression studies of COS-7 cells lacking endogenous ER, E ( 2 ) treatment of COS-7 cells did not alter
NOS2A reporter activity in the
presence of
ESR1 , while reporter activity increased 2.3-fold in the presence of ESR2
Cignarella et al., J Pharmacol Exp Ther 2009
(Diabetes Mellitus, Experimental...) :
Distinct
roles of
estrogen receptor-alpha and beta in the modulation of vascular inducible
nitric-oxide synthase in diabetes ... In cultured aortic rings from both normoglycemic and STZ-diabetic mice, pharmacological activation of
ER alpha attenuated cytokine-driven
iNOS induction by 30 to 50 %
Fan et al., J Steroid Biochem Mol Biol 2009
:
The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by
estrogen receptor activation and
inhibition of
iNOS