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NFKB1 — TRADD

Pathways - manually collected, often from reviews:

• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF) → NF kappa B1/RelA complex (NFKB1-RELA) (modification, activates)
  Sanz et al., EMBO J 1999, Leitges et al., Mol Cell 2001
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• Gene Ontology Complexes protein complex: protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3) Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998

Text-mined interactions from Literome

Kieser et al., EMBO J 1999 (Cell Transformation, Neoplastic) : Whereas NF-kappaB activation by LMP1 was blocked by a dominant negative TRADD mutant, LMP1 induces JNK1 independently of the TRADD death domain and TRAF2, which binds to TRADD
Puls et al., J Cell Sci 1999 (Inflammation) : Using LMP1 mutants, we show that activation of Cdc42 and JNK/NF(kappa)B occur through distinct pathways and that Cdc42 activation is independent of LMP1 's interaction with TRADD and TRAF proteins
Majumder et al., Virology 2002 : Furthermore, NS5A prevented the association between TRADD and FADD and blocked TRADD mediated NF-kappaB activation
Hu et al., J Biol Chem 2004 : TNAP specifically inhibits NF-kappaB activation induced by tumor necrosis factor (TNF)-alpha, TNF receptor 1, TRADD , RIP, TRAF2, and NIK but does not affect IKK1- and IKK2 mediated NF-kappaB activation
Imamura et al., J Biol Chem 2004 (Inflammation) : However, TRADD and RIP, which are essential for the TNF-alpha induced NF-kappaB activation, were not involved in the FasL induced NF-kappaB activation
Shishodia et al., Cancer Res 2005 (Carcinoma, Small Cell...) : NF-kappaB dependent reporter gene expression was also suppressed by 4-HPR, as was NF-kappaB reporter activity induced by TNFR1, TRADD , TRAF2, NIK, and IKK but not that induced by p65 transfection
Zheng et al., Mol Cell Biol 2006 : We found that TRADD is required for TNFR1 to induce NF-kappaB activation and caspase-8 dependent apoptosis but is dispensable for TNFR1 initiated, RIP1 dependent necrosis
Sung et al., Mol Pharmacol 2007 : NF-kappaB dependent reporter gene expression was also suppressed by fisetin, as was NF-kappaB reporter activity induced by TNFR1, TRADD , TRAF2, NIK, and IKK but not that induced by p65 transfection
Sethi et al., Oncogene 2007 (Adenocarcinoma...) : Using dominant negative plasmids, we also demonstrated the role of TRADD , TRAF2, NIK and Ras in EGF induced NF-kappaB activation
Hong et al., BMC molecular biology 2007 : Zfra affects TNF mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB , JNK1, p53 and WOX1 during stress response
Sethi et al., J Immunol 2007 : NF-kappaB reporter assay revealed that NF-kappaB activation induced by TNF, TNFR1, TRADD , TRAF2, NIK, and I kappaB alpha kinase was modulated in gene deleted cells
Sethi et al., Biochem Pharmacol 2008 (Neoplasm Invasiveness) : This led to suppression of the phosphorylation and translocation of p65 and also of NF-kappaB reporter activity induced by TNFR1, TRADD , TRAF2, NIK, and IKKbeta but not that induced by p65 transfection
Ermolaeva et al., Nat Immunol 2008 : Moreover, TRADD deficiency inhibited poly ( I:C ) -mediated RIP1 ubiquitination and activation of NF-kappaB and mitogen activated protein kinase signaling in fibroblasts but not in bone marrow macrophages
Kieser et al., Biol Chem 2008 : TRADD mediates TNFR1 activation of NF-kappaB and c-Jun N-terminal kinase (JNK), as well as caspase dependent apoptosis ... The unique structure of the LMP1-TRADD complex dictates an unusual type of TRADD dependent NF-kappaB signaling and subverts TRADD 's potential to induce apoptosis
Wang et al., Cancer Res 2009 (Disease Progression...) : Knocking down TRADD expression in LNCaP cells impaired TNF-alpha induced NF-kappaB activation and androgen receptor repression, whereas overexpression of TRADD in C4-2B cells restored their sensitivity to TNF-alpha
Hsu et al., Cell 1995 : Overexpression of TRADD leads to two major TNF induced responses, apoptosis and activation of NF-kappa B ... However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF induced cell death and NF-kappa B activation are distinct
Hsu et al., Immunity 1996 : The death domain of tumor necrosis factor (TNF) receptor-1 ( TNFR1 ) triggers distinct signaling pathways leading to apoptosis and NF-kappa B activation through its interaction with the death domain protein TRADD
Tewari et al., Curr Opin Genet Dev 1996 : TRADD , which contains a novel ` death domain ' that binds to the corresponding death domain in the cytoplasmic segment of TNFR1, can mediate both activation of NF-kappa B and induction of apoptosis, the two major responses signaled by TNFR1
Shu et al., Proc Natl Acad Sci U S A 1996 : The association of TRADD , a 34-kDa cytoplasmic protein containing a C-terminal death domain, with aggregated TNF receptor 1 (TNF-R1) through their respective death domains leads to NF-kappa B activation and programmed cell death
Izumi et al., Proc Natl Acad Sci U S A 1997 (Cell Transformation, Neoplastic...) : In transfection assays, TRADD and TES2 synergistically mediated high-level NF-kappaB activation