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ANGPT2 — STAT3

Text-mined interactions from Literome

van Eickels et al., Naunyn Schmiedebergs Arch Pharmacol 1999 : Stimulation with Ang II ( 10 ( -7 ) M ) also led to an increased phosphorylation of STAT3 , which is one of the key effector proteins in the JAK/STAT signalling pathway
Sahar et al., Circ Res 2005 (Arteriosclerosis...) : Finally, dominant negative STAT-3 mutant blocked Ang II-induced IL-18Ralpha promoter activation in CHO cells overexpressing AT1a receptor and IL-18Ralpha mRNA expression in HVSMC
Tsai et al., Circulation 2008 (Atrial Fibrillation...) : In cultured atrial myocytes and fibroblasts, Ang II induced tyrosine phosphorylation of STAT3 through a Rac1 dependent mechanism, which was inhibited by dominant negative Rac1, losartan, and simvastatin
Weng et al., Alcohol 2008 : In the presence of U-0126 ( 10microM ), a p42/44 mitogen activated protein kinase ( MAPK ) kinase inhibitor, Ang II further increased Tyr705 phosphorylation of STAT3 but completely abrogated Ser727 phosphorylation of STAT3
Giani et al., Exp Physiol 2008 : Both ANG II and ANG- ( 1-7 ) increased STAT3 and STAT5a/b phosphorylation to a similar extent ( 130-140 % increase )
Kandalam et al., Regul Pept 2010 : Ang II also stimulated STAT3 in a concentration- and time dependent manner ... Our study showed for the first time that Ang II induced JAK2/STAT3 phosphorylation and IL-6 secretion through activation of the Ang II AT(1) receptor in brainstem astrocytes
Dostal et al., J Mol Cell Cardiol 1997 : It has been shown that Ang II stimulates the tyrosine phosphorylation and nuclear translocation of Stat1 ( Stat 91 ) and Stat3 ( Stat 92 )
Bhat et al., Basic Res Cardiol 1998 : In cultured neonatal rat cardiac fibroblasts and CHO-K1 cells expressing angiotensin II (Ang II) type 1 receptors ( AT1 ) ( T3CHO/AT1A cell line ), Ang II induced a delayed tyrosine phosphorylation of Stat3 ( Signal Transducers and Activators of Transcription ) with maximal activation at 2 h