Gene interactions and pathways from curated databases and text-mining

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NAMPT — SIRT1

Text-mined interactions from Literome

Wang et al., Nature structural & molecular biology 2006 : Nicotinamide phosphoribosyltransferase ( Nampt ) synthesizes nicotinamide mononucleotide ( NMN ) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo
Lovren et al., Am J Physiol Endocrinol Metab 2009 (Atherosclerosis...) : Visfatin , a NAD biosynthetic enzyme, regulates the activity of the cellular survival factor, Sirt1
Zhang et al., J Cell Biochem 2010 : Thus, the effect of Nampt on Tat regulated SIRT activity was studied in Hela-CD4-beta-gal ( MAGI ) cells