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FYN — MAPK1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/ERK2/m-calpain complex (PTK2-YES1_SRC_FYN-MAPK1-CAPN2)
→
ERK2 (MAPK1)
(modification, collaborate)
Cuevas et al., EMBO J 2003, Carragher et al., Curr Biol 2003, Westhoff et al., Mol Cell Biol 2004, Sawhney et al., J Biol Chem 2006
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/ERK2/m-calpain complex (PTK2-YES1_SRC_FYN-MAPK1-CAPN2)
→
FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN)
(modification, collaborate)
Cuevas et al., EMBO J 2003, Carragher et al., Curr Biol 2003, Westhoff et al., Mol Cell Biol 2004, Sawhney et al., J Biol Chem 2006
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/ERK2/m-calpain complex (PTK2-YES1_SRC_FYN-MAPK1-CAPN2)
→
m-calpain (CAPN2)
(modification, collaborate)
Cuevas et al., EMBO J 2003, Carragher et al., Curr Biol 2003, Westhoff et al., Mol Cell Biol 2004, Sawhney et al., J Biol Chem 2006
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
ERK2 (MAPK1)
→
FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN)
(modification, collaborate)
Cuevas et al., EMBO J 2003, Carragher et al., Curr Biol 2003, Westhoff et al., Mol Cell Biol 2004, Sawhney et al., J Biol Chem 2006
Evidence: assay, physical interaction, other species
Text-mined interactions from Literome
Petridis et al., Dev Dyn 2004
(Neuroblastoma) :
This differentiation involved
activation of
mitogen activated protein kinase through
p59fyn and was blocked by its inhibition
Wagner et al., PloS one 2008
:
SLK activation is
dependent on
FAK/c-src/MAPK signaling, whereas SLK recruitment to the leading edge is src dependent but FAK independent
Yadav et al., Mol Carcinog 2011
:
Activation of Akt, but not
MAPK or EGFR, was
necessary and sufficient for induction of
Fyn by H-Ras