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CCND1 — MYC
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Li et al., J Biol Chem 1999
:
By measuring [ ( 3 ) H ] thymidine incorporation, it was found that expression of
Myc-CK2beta prolonged the G ( 1 ) phase and
inhibited up-regulation of
cyclin D1 expression during G ( 1 )
Doisneau-Sixou et al., Endocr Relat Cancer 2003
(Breast Neoplasms) :
An antisense mediated decrease in
c-Myc expression
results in decreased
cyclin D1 expression and inhibition of DNA synthesis, mimicking the effects of antiestrogen treatment and emphasizing the importance of c-Myc as an estrogen/antiestrogen target
Yang et al., Hepatology 2009
(Cholestasis...) :
Switch from Mnt-Max to
Myc-Max induces p53 and
cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes ... The current work tested the hypothesis that the switch from Mnt-Max to
Myc-Max is
responsible for p53 and
cyclin D1 up-regulation and apoptosis during cholestasis
Amendola et al., Cell Prolif 2009
(Astrocytoma) :
Myc down-regulation
affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line
Hu et al., Journal of translational medicine 2009
(Nasopharyngeal Neoplasms) :
Immunoblot analysis showed that expression of
c-Myc protein was significantly downregulated by ApoG2 and that the expression of c-Myc 's downstream molecules
cyclin D1 and cyclin E were
inhibited whereas p21 was induced
Sun et al., Oncogene 2013
(Neoplasms) :
Cyclin D1 inhibited RSK4 expression and serum starvation enhanced the inhibition, whereas
c-Myc and RSK4
inhibited cyclin D1
Steiner et al., EMBO J 1995
:
We now report that induction of
Myc in density arrested fibroblasts
triggers rapid hyperphosphorylation of the retinoblastoma protein and activation of both
cyclin D1- and cyclin E-associated kinase activities in the absence of significant changes in the amounts of cyclin-cdk complexes
Philipp et al., Mol Cell Biol 1994
:
Constitutive expression of human
MYC represses mRNA levels of
cyclin D1 in proliferating BALB/c-3T3 fibroblasts ... In particular, we found that association with Max is not required for
repression of
cyclin D1 by
MYC in vivo ... Expression of
MYC represses the
cyclin D1 promoter via core promoter elements and antagonizes USF mediated transactivation
Jansen-Dürr et al., Proc Natl Acad Sci U S A 1993
:
In synchronized cells,
repression of
cyclin D1 by
MYC occurred very early in the G1 phase of the cell cycle