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IRF8 — TLR5
Text-mined interactions from Literome
Hickey et al., J Leukoc Biol 2008
:
Adenylate cycalse toxin of Bordetella pertussis inhibits
TLR induced IRF-1 and
IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
Knödler et al., Leukemia 2009
:
IL-10 was found to downregulate MyD88, IRAK1 ( IL-1 receptor associated kinase ) and tumor necrosis factor receptor associated factor 6, essential adaptor molecules for TLR signaling, and to decrease
TLR induced nuclear expression of the nuclear factor-kappaB transcription factors c-Rel and Rel-B as well as interferon regulatory factor (IRF)-3 and
IRF-8
Atzei et al., J Biol Chem 2010
:
We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses
TLR induced
activation of NF-?B and
interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses