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NOS2 — RENBP

Text-mined interactions from Literome

McCarthy et al., BMC cell biology 2001 : After a 24-hour culture, AGE-collagen increased the expression of endothelial and inducible NOS , in both osteoblastic cell lines
Kuniyasu et al., Int J Cancer 2003 (Colorectal Neoplasms...) : In contrast, production of inducible nitric oxide synthase and nuclear factor-kappaBp65 were increased to a greater degree by AGE-BSA than by amphoterin
Xu et al., FASEB J 2003 (Diabetes Mellitus) : In HUVEC, AGE-Glu inhibited endothelial nitric oxide synthase activity, and this was associated with a decrease in serine phosphorylation of this enzyme
Wu et al., Biochem Pharmacol 2003 : Role of protein kinase C in BSA-AGE mediated inducible nitric oxide synthase expression in RAW 264.7 macrophages ... The tyrosine kinase inhibitor ( genistein ), the phosphatidylinositol-specific phospholipase C inhibitor ( U-73122 ), the phosphatidylcholine-specific phospholipase C inhibitor ( D-609 ), and the PKC inhibitors ( staurosporine, Ro 31-8220, and Go 6976 ) all inhibited BSA-AGE induced NO release and iNOS expression in RAW 264.7 cells
Chang et al., Kidney Int 2004 (MAP Kinase Signaling System) : In the present study, we investigated the effects of AGEs on inducible nitric oxide synthase (iNOS) expression and nitric oxide production, and the effects of rosiglitazone, an activator of PPAR-gamma, on AGE induced iNOS expression and nitrite release in glomerular mesangial cells ... A protein tyrosine kinase inhibitor ( genistein ), or a p38 mitogen activated protein kinase ( MAPK ) inhibitor ( SB203580 ) suppressed AGE induced iNOS expression and nitrite release from mesangial cells ... Activation of PPAR-gamma by rosiglitazone inhibited AGE induced iNOS expression, nitrite release, and p38 MAPK activation in mesangial cells ... AGE induced iNOS expression was inhibited by treatment with a nuclear factor-kappaB (NF-kappaB) inhibitor, pyrrolidone dithiocarbamate ... These data suggest that cytokine release, NF-kappaB and p38 MAPK dependent pathways may play a role in AGE induced iNOS expression and subsequent nitric oxide production in mesangial cells ... Rosiglitazone may prevent AGE induced iNOS expression by interfering with p38 MAPK activity
San Martin et al., Free Radic Biol Med 2007 (Vascular Diseases) : This study establishes that AGE activate iNOS in VSMC through a ROS-sensitive, NF-kappaB dependent mechanism involving ROS generation by a Nox1 based oxidase
Linden et al., Clin J Am Soc Nephrol 2008 (Hyperemia...) : Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE) mediated inhibition of endothelial nitric oxide synthase through RAGE activation
Nah et al., Rheumatology (Oxford) 2008 (MAP Kinase Signaling System...) : Pre-treatment with soluble receptor for AGE ( sRAGE ) also reduced AGE stimulated COX-2, iNOS and PGE ( 2 ), implicating the involvement of RAGE
Huang et al., Eur J Clin Invest 2009 (Osteoarthritis) : AGE potently induced COX-2-PGE ( 2 ) and iNOS-NO activation in porcine and human chondrocytes
Seftel et al., Urology 1997 (Diabetes Mellitus, Type 1...) : Because AGE mediated effects may involve inducible nitric oxide synthase (iNOS) , we performed immunohistochemical and Western blot analysis of diabetic and nondiabetic human penile tissue for iNOS