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CUL1 — TMED7

Text-mined interactions from Literome

Tsvetkov et al., Curr Biol 1999 : p27 ( Kip1 ) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
Cen et al., J Biol Chem 2009 : Taken together, our findings indicate that HINT1 up-regulates cellular levels of p27 ( KIP1 ) by two mechanisms : 1 ) it inhibits its ubiquitylation by targeting the SCF ( SKP2 ) ubiquitin ligase complex, and 2 ) it inhibits the phosphorylation of p27 ( KIP1 ) by Src via inhibiting Src expression