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PARP1 — TFAP2A

Text-mined interactions from Literome

Li et al., Biochem J 2004 (Breast Neoplasms...) : Dual regulation of AP-2alpha transcriptional activation by poly(ADP-ribose) polymerase-1 ... In the present study, we find that the role of PARP-1 in AP-2alpha transcription is distinctly dualistic with opposing effects ... We hypothesize that PARP-1 enhances the transcriptional activity of AP-2alpha in normal circumstances, whereas its enzymic activity is used as a temporary shut-off mechanism during unfavourable conditions
Kannan et al., Nucleic Acids Res 1999 : PARP suppresses AP-2 self-inhibition and enhances AP-2 activity in PA-1 cells indicating that it is a coactivator for AP-2-transcription ... PARP significantly restores AP-2 transcriptional activity in ras oncogene transformed cells suggesting that it might suppress transformation in these cells