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ESR1 — PI3

Text-mined interactions from Literome

Campbell et al., J Biol Chem 2001 (Breast Neoplasms) : Here we show that phosphatidylinositol (PI) 3-kinase and AKT activate ERalpha in the absence of estrogen ... Although PI 3-kinase increased the activity of both estrogen independent activation function 1 (AF-1) and estrogen dependent activation function 2 ( AF-2 ) of ERalpha , AKT increased the activity of only AF-1
Sun et al., Cancer Res 2001 (Breast Neoplasms) : Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2 , activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K
Pozo-Guisado et al., Int J Cancer 2004 (Breast Neoplasms) : Recent data have indicated that the estrogen receptor-alpha (ERalpha) , through interaction with p85, regulates phosphoinositide 3-kinase (PI3K) activity, revealing a physiologic, nonnuclear function of the ERalpha potentially relevant in cell proliferation and apoptosis
Bhat-Nakshatri et al., Br J Cancer 2004 (Breast Neoplasms...) : From these results, we propose that TNFalpha expression or PI3-kinase activation lead to reduced levels of ERalpha protein in cancer cells and corresponding loss of transrepression function and acquisition of an invasive phenotype
Hwang et al., Toxicol Appl Pharmacol 2008 : Recent studies have indicated that the estrogen receptor ( ER ) , through interaction with p85, regulates phosphoinositide 3-kinase (PI3K) activity, revealing a physiologic, non-nuclear function of ER that may be relevant in cytoprotection