◀ Back to MMP2
MMP2 — WDR61
Text-mined interactions from Literome
Axelrad et al., FASEB J 2004
(Adenocarcinoma...) :
Platelet activating factor (PAF) induces activation of
matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration
Ottino et al., Invest Ophthalmol Vis Sci 2005
:
PAF , through a receptor mediated mechanism,
induces a specific pattern of furin,
MMP , and TIMP-2 expression in corneal myofibroblasts
Melnikova et al., J Biol Chem 2006
(Melanoma...) :
Furthermore,
PAF stimulated the gelatinase activity of
MMP-2 by activating transcription and MMP-2 expression ...
PAF induced expression of
pro-MMP-2 was causally related to PAF induced CREB and ATF-1 phosphorylation ; it was prevented by PAFR antagonist and inhibitors of p38 MAPK and protein kinase A and was abrogated upon quenching of CREB and ATF-1 activities by forced overexpression of a dominant negative form of CREB ...
PAF induced
MMP-2 activation was also down-regulated by p38 MAPK and protein kinase A inhibitors
Zhou et al., Am J Physiol Heart Circ Physiol 2007
:
Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that PAF induced the release of HB-EGF within 1 min. Gelatin zymography data showed that
PAF stimulated
MMP-2 activity and MMP-9 activity within 1 min
Melnikova et al., Cancer Metastasis Rev 2007
(Inflammation...) :
Furthermore, we showed that
PAF stimulated the phosphorylation of CREB and ATF-1 in metastatic melanoma cells, which resulted in overexpression of
MMP-2 and MT1-MMP