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CDK2 — RBBP4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation) Litovchick et al., Mol Cell 2007
• IRef Intact Interaction: Complex of 14 proteins (association, anti bait coimmunoprecipitation) Litovchick et al., Mol Cell 2007

Text-mined interactions from Literome

Kim et al., J Antibiot (Tokyo) 2000 (Colorectal Neoplasms) : These results suggest that the suppression of Cdk2 kinase activity due to p21 overexpression play a critical role in HDAC inhibitor induced growth inhibition
Hitomi et al., FEBS Lett 2003 : Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin dependent kinase inhibitor, p21 ( WAF1/Cip1 )
Li et al., Cancer Res 2010 (Colonic Neoplasms) : HDAC depletion relieved HDAC mediated transcriptional inhibition of the cyclin dependent kinase inhibitors p21WAF1 and p27KIP2, significantly increasing their expression and triggering cell cycle arrest in the G(2) phase of the cell cycle
Findeisen et al., Arterioscler Thromb Vasc Biol 2011 (Disease Models, Animal...) : HDAC inhibition resulted in a transcriptional and posttranscriptional regulation of the cyclin dependent kinase inhibitors p21 ( Cip1 ) and p27 ( Kip )