Liu et al., Life Sci 2004
(MAP Kinase Signaling System) :
PGH ( 2 ), PGD ( 2 ) and its metabolites of the PGJ ( 2 ) series, and PGA ( 1 ) markedly induced the protein expression of HO-1 Satarug et al., Biochem Biophys Res Commun 2008
:
We have shown that PGD ( 2 ) induces the expression of heme oxygenase-1 (HO-1) in the retinal pigment epithelium (RPE) that is essential for survival of photoreceptors ... Thus, PGD ( 2 ) induces HO-1 mRNA expression through DP2 receptor, linking the PGD ( 2 ) -DP2 signaling with heme homeostasis
Kuesap et al., Korean J Parasitol 2010
(Malaria, Cerebral...) :
Thus, PGD ( 2 ) may be involved in the pathogenesis of cerebral malaria by inducing HO-1 expression in malaria patients