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ICAM1 — TNFRSF8

Text-mined interactions from Literome

Nam et al., Cell Immunol 2002 : Regulation of lymphocyte clustering by CD30 mediated ICAM-1 up-regulation ... CD30 mediated ICAM-1 up-regulation is independent of cytokine secretion and appears to be transmitted directly through NF-kappaB activation ... CD30 mediated up-regulation of ICAM-1 expression led to a significant increase in cluster formation of lymph node cells
Uchihara et al., Int J Cancer 2006 (Hodgkin Disease) : CD30 induced ICAM-1 expression ... Analysis of the ICAM-1 promoter showed the importance of NF-kappaB binding site for CD30 induced ICAM-1 gene expression ... Coexpression of IkappaB, IKK, NIK and TRAF dominant negative constructs with CD30 inhibited CD30 induced activation of ICAM-1 promoter, suggesting that CD30 induces ICAM-1 via NF-kappaB signalling ... A decoy CD30 lacking the cytoplasmic region inhibited ICAM-1 promoter activity in HL cell lines ... Thus, in H/RS cells, ligand independent activation of CD30 signalling activates NF-kappaB and this leads to constitutive ICAM-1 expression, suggesting a link between 2 well known phenotypic characteristics of HL, CD30 and ICAM-1 overexpression
Gruss et al., Eur J Immunol 1995 (Hodgkin Disease) : Further, CD30L enhanced surface expression of intercellular adhesion molecule-1 ( ICAM-1/CD54 ) on cultured H-RS cells, which is frequently overexpressed on primary H-RS cells