Madura et al., EMBO Rep 2004
(Spinal Cord Injuries) :
Recent evidence suggests that these proteins inhibit neurite outgrowth by activation of Rho through the neurotrophin receptor p75 ( NTR ) /Nogo receptor complex
Zvibel et al., Lab Invest 2010
(Liver Cirrhosis) :
Thyroid hormones induce activation of rat hepatic stellate cells through increased expression of p75 neurotrophin receptor and direct activation of Rho Choi et al., Mol Neurobiol 2012
:
Treatment with bFGF activated the RhoA/Rho associated kinase (ROCK)/c-jun N-terminal kinase ( JNK ) pathway, and bFGF induced NT-3 expression was blocked by a dominant negative RhoA as well as by a specific Rho-kinase inhibitor ( Y27632 ) and a SAPK/JNK inhibitor ( SP600125 )