Vargha et al., Nephrol Dial Transplant 2008
:
In vivo ` chronic ' EMT resulted in lower expression of HSP-27 and HSP-72, whereas in vitro ` acute ' EMT was associated with increased HSP-27 and decreased HSP-72 expression
Wettstein et al., FASEB J 2013
(Fibrosis) :
Inhibition of HSP27 with OGX-427 efficiently blocks EMT and fibrosis development
Shiota et al., Cancer Res 2013
(Neoplasm Metastasis...) :
Mechanistically, silencing Hsp27 decreased IL-6 dependent STAT3 phosphorylation, nuclear translocation, and STAT3 binding to the Twist promoter, suggesting that Hsp27 is required for IL-6 mediated EMT via modulation of STAT3/Twist signaling