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AKT1 — CDH13
Text-mined interactions from Literome
Joshi et al., FASEB J 2007
:
ILK-siRNA abolished
T-cad dependent effects on ( Ser-473 )
Akt/ ( Ser-9 ) GSK3beta phosphorylation, active beta-catenin accumulation, and survival
Zhou et al., Mol Cancer Ther 2009
(Lung Neoplasms...) :
Luteolin inhibits mdm2 through AKT and overexpression of active
AKT attenuated luteolin induced expression of
E-cadherin , suggesting that luteolin regulates E-cadherin through AKT/mdm2 pathway
Joshi et al., FASEB J 2009
:
Similarly to overexpression of native T-cad, cells expressing DeltaII, DeltaIII, or DeltaIV displayed elevated levels of p-Akt and p-GSK3beta and increased proliferation rates ( for DeltaII, DeltaIII ) vs. E. DeltaI- and DeltaV transduced cells exhibited reduced levels of p-Akt and p-GSK3beta and retarded growth rates vs. E. Stimulatory
effects of native
T-cad overexpression on
Akt and GSK3beta phosphorylation were dose dependently inhibited by coexpression of DeltaI or DeltaV
Philippova et al., Eur Heart J 2011
(Coronary Artery Disease) :
Gain-of-function and loss-of-function studies demonstrate that MP-bound
T-cad induced
Akt phosphorylation and activated angiogenic behaviour in target ECs via homophilic based interactions
Cheng et al., J Clin Endocrinol Metab 2012
:
Moreover, the inhibition of EGF induced ERK1/2, p38, and
Akt activation by pharmacological inhibitors
attenuated EGF induced Slug expression and the down-regulation of
E-cadherin , as well as subsequent cell invasion
Kisslov et al., Biochim Biophys Acta 2012
(Colonic Neoplasms) :
AS or Ly294002, but not H-89, decreased
PKB/Akt activation as well as the nuclear localization of ß-catenin and cyclin D1 and
increased the plasma membrane localization of ß-catenin with
E-cadherin , suggesting that these processes are regulated by the PKB pathway ... AS or Ly294002, but not H-89, decreased
PKB/Akt activation as well as the nuclear localization of ß-catenin and cyclin D1 and
increased the plasma membrane localization of ß-catenin with
E-cadherin , suggesting that these processes are regulated by the PKB pathway